应用全颌曲面断层片判断牙周炎骨密度和预测下颌角骨折风险的研究

目的：应用一种新的全颌曲面断层分析方法来判断牙周炎组和正常组之间的相对骨密度（RBD）的差异,并预测下颌角骨折的风险.方法：回顾性研究60例牙周炎患者和60例正常组病例,应用全颌曲面断层片比较其相对骨密度（RBD）.同时,调查所有患者的下颌角骨折病史并做记录.结果：牙周炎组和正常组之间的三个RDB指数的差异有明显统计学意义.正常组有3例下颌角骨折患者,牙周炎组有8例下颌角骨折病例.两组下颌角骨折患者RBD指数均相对较低.结论：牙周炎组和正常组的RBD指数之间具有明显统计学意义,RBD指数可以作为普通全颌曲面断层片的一种新的分析方法.可用做牙周炎的筛选工作,并在一定程度上可以预测发生下颌角骨折的风险.     

钟摆矫治器联合颊侧推簧远移磨牙的疗效分析

目的：评价钟摆矫治器联合颊侧推簧远移磨牙的疗效.方法：选择40例牙性安氏Ⅱ类错（牙合）畸形的患者,随机均分为两组：钟摆矫治器联合颊侧推簧远移磨牙组（组1）和头帽口外弓远移磨牙组（组2）,在治疗开始前（T0）和远移磨牙完成时（T1）分别拍摄侧位头影定位片进行头影测量,t检验分析组内和组间的差异.结果：组1和组2远移磨牙的平均距离分别是（4.48±1.63） mm、（2.68±1.71） mm;组1和组2磨牙远中倾斜的平均角度分别是5.46°±3.23°、1.02°±2.16°;组1上颌中切牙未发生明显的唇倾和唇向移位,而组2上颌中切牙发生了较为明显的腭侧移位.结论：钟摆矫治器联合颊侧推簧远移磨牙可有效防止前牙支抗的丧失、控制磨牙的近中颊侧旋转.     

环孢素 A 对大鼠牙槽骨内 DMP1 C 末端和 OPN 表达的影响

目的：观察环孢素A（cyclosporinA,CsA）对大鼠牙槽骨内牙本质基质蛋白1（dentinmatrixprotein,DMP1）C末端和骨桥蛋白（osteopontin,OPN）表达的影响。方法：30只7周龄健康雄性Wistar大鼠,随机等分为对照组和实验组,每组再随机等分为20d、30d和40d3个亚组,实验组大鼠喂饲CsA（30mg／k·d）。免疫组化法染色下颌第一磨牙颊舌向石蜡切片,光镜下观察DMP1C末端和OPN在牙槽骨内的表达情况。结果：与对照组大鼠比较,实验组大鼠牙槽骨内DMP1C末端表达明显下调,OPN表达明显上调;在本实验周期内,上述变化随实验时间的延长而加重。结论：CsA影响大鼠牙槽骨内矿化相关非胶原蛋白DMP1C末端和OPN的表达,推测CsA可能抑制大鼠牙槽骨的矿化。     

正畸用光固化玻璃离子粘接剂联合麻花丝技术在外伤牙固定中的应用

目的：寻找一种椅旁操作时间短、程序简单、固定效果佳的粘接系统在外伤牙固定治疗中的应用。方法：选择外伤松动牙患者78例共计139颗患牙,随机分为实验组71颗忠牙,采用正畸用光固化玻璃离子粘接剂＋麻花丝固定,对照组68颗患牙采用全酸蚀粘接树脂＋麻花丝固定,固定2-4周时去除固定装置。拆除固定装置6个月后复查,对患牙的疗效进行评价。结果：拆除固定装置6个月后实验组成功率92．9％,对照组成功率91．2％,两组病例差异无统计学意义。结论：正畸用光固化玻璃离子粘接剂＋麻花丝固定外伤松动牙的疗效和稳固性可达到全酸蚀粘接＋麻花丝树脂固定的水平,但前者操作简单,适宜临床应用。     

Strategies for assessing the prevalence of cardiovascular sudden deaths in young competitive athletes

Background/Objectives

Prevalence/incidence of sudden death due to cardiovascular disease in young competitive athletes has become an important part of the debate over the most effective and practical preparticipation screening strategies for this population. Since event reporting is not mandatory, identification of cases has been achieved largely through publicly available data and internet searches. The accuracy of this methodology has not been studied and deserves scrutiny.

Methods

We assessed recognition of sudden cardiovascular deaths in college (NCAA) athletes with the U.S. National Registry of Sudden Death in Athletes that uses largely public domain sources, and also the NCAA Memorial Resolutions List.

Results

For 2002–2011, 64 total sudden death cases were identified by both sources. The Registry identified 56 cases (88%), including 14 not found in the NCAA List. The NCAA List identified 50 cases (78%), including 8 unrecognized by the Registry (p = 0.16). Failure to initially recognize these 8 deaths using established Registry search mechanisms was due to the absence of key search terms in media reports. Cases not identified by the 2 methodologies did not differ significantly regarding demographics, cause of death, or sport.

Conclusions

Internet-based, public domain methodology is useful and identified more cases of sudden cardiovascular death in college athletes than did the internal list provided by the NCAA. Nevertheless, these findings support the principle that multiple sources are additive and beneficial in identifying the maximum number of sudden death events.     

心理干预对胃癌患者心理健康状况的影响

目的探讨心理干预对胃癌患者心理状况的影响。方法对32例胃癌患者进行心理状况调查。根据每个患者的测评结果实施有针对性的心理与行为方式干预措施，比较干预前后患者心理健康状况。结果心理干预前后。除偏执症状外，患者的强迫、人际关系敏感、抑郁、敌对、惊恐、精神病性等维度评分均存在统计学差异（均P〈0．05）。结论心理干预对胃癌患者负性心理状况有明显改善作用。     

慢性乙型肝炎患者血清角蛋白18裂解片段及其应用研究进展

近年来,血清角蛋白18及其裂解片段在肝病诊断方面的应用潜力引起了国内外研究者的强烈兴趣,但其在慢性乙型肝炎方面的应用研究较少。该文总结和探讨了循环血角蛋白18裂解片段M30及M65水平变化在慢性乙型肝炎中的意义以及应用前景。     

La mesure d'indépendance fonctionnelle (MIF) a-t-elle une valeur prédictive dans les accidents vasculaires cérébraux?

Objective: Assessment of the predictive value of functional independence measure (FIM) for hemiplegie patients after ischemic stroke. Method: Comparison between functional status at admittance and at discharge, this status being assessed by FIM. Population: From 11/01/92 to 04/30/93, 172 hemiplegic patients, admitted after ischemic brain lesion (30 to 94 years old, mean 72; 92 male and 80 female), were included in this study. Motor and/or cognitive deficit had been regressive for 51 patients (29.8%). Lesion was hemispheric in 119 cases: 54% right, 45% left. Results: Total regressive deficits were associated with the highest admittance FIM (a-FIM) and discharge FIM (d-FIM), 100 and 114 respectively. For partially regressive deficits with sequelae, the benefit was 22, and for the most severe deficit, it was only 4. Hemispheric lesions had lower a-FIM and d-FIM than non-hemispheric brain lesions, and benefit was lower. If right hemiplegic patients had lower scores than left, it was due to aphasia, and benefit was not significantly different between these two groups. Discussion: FIM appears to be a good indicator for discharge status, but successful discharge to home is very unprobable when a-FIM is close to 40. Correlation between FIM and the real load of nursing would have to be evaluated.     

中医药快速抗抑郁研究进展

摘要：目的 观察通督调神针刺法结合认知疗法干预卒中后抑郁的临床效应,并探讨其疗效可能的作用机制。方法 将60例卒中后抑郁患者随机分为观察组和西药组,每组30例,两组在予以脑血管疾病基础治疗的同时,采用不同方法干预,观察组采用通督调神针刺法结合认知疗法治疗,西药组予以盐酸帕罗西汀片口服,疗程均为4周,治疗前后进行汉密尔顿抑郁量表(HAMD)、日常生活能力评定（Barthel指数）及副反应量表( TESS) 评估,观察两组临床疗效,测定患者血清 5-HT水平。结果 同组治疗后较治疗前比较,HAMD评分均显著降低(P<0.05),Barthel 指数均提高（P＜0.05）,组间比较,观察组优于西药组,差异具有统计学意义(P<0.05),治疗后两组血清 5-HT水平均较治疗前升高 (P<0.05) ,两组5-HT升高幅度比较无统计学意义(P>0.05),观察组总有效率为93. 3%,西药组为86.7%,两组比较差异具有统计学意义(P<0.05),观察组不良反应发生率较西药组发生率低,差异有统计学意义(P<0.05)。结论 通督调神针刺法结合认知疗法法干预卒中后抑郁,可以显著改善 PSD 患者的抑郁状态,其疗效机制可能与血清 5-HT水平上调有关,通督调神针刺法结合认知疗法是治疗卒中后抑郁行之有效、副反应低、操作重复性好的临床治疗手段。     

基于抑郁模型大鼠miR-665表达及靶基因功能分析探讨开心解郁方抗抑郁疗效机制

摘 要：目的：检测中药开心解郁方干预抑郁症模型大鼠过程中海马miR-665表达变化并对miR-665的靶基因进行生物信息分析,探讨miR-665在抑郁症的发病及开心解郁方抗抑郁机制中的作用。方法：建立慢性应激抑郁症大鼠模型并用开心解郁方干预42天,取海马组织提取总RNA,采用RT-qPCR检测各组大鼠海马miR-665相对表达量,采用TargetScan和microRNAorg数据库对miR-665进行靶基因预测,采用DAVID数据库对预测得到的靶基因进行GO功能富集分类及KEGG信号通路分析。结果：与正常组比较,模型组大鼠海马miR-665表达水平显著增高,差异具有统计学意义（P<0.01）;与模型组比较,中药组及西药组大鼠海马miR-665表达水平显著降低,差异具有统计学意义（P<0.05）。miR-665靶基因的生物学功能主要富集于有机物质反应等;信号通路主要富集于N-糖链的合成等。结论：miR-665可能参与了抑郁症病理机制过程调控,通过改善其表达异常可能为开心解郁方的抗抑郁机制之一,通过对其靶基因的功能预测分析对于后期继续研究开心解郁方干预miR-665的具体作用机制提供了方向和理论基础。